HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Sulfate → 8-Bromo-6-methoxyisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | 8-Bromo-6-methoxy-1,2,3,4-tetrahydroisoquinoline | HCID 67403974 | — |
| Catalyst | HCID 178418406 | HCID 178418406 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 8-Bromo-6-methoxyisoquinoline | HCID 59534747 | 35.7% |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
Sodium sulfate (2.8 g) and manganese dioxide (7.1 g; Ald) were added to a toluene (60 mL) solution of Intermediate 5 (1.99 g) and the resulting mixture was stirred at 140° C. for 24 hours. The reaction mixture was filtrated through celite followed by the addition of 2 N hydrochloric acid and the resulting mixture was washed with ether. The resulting mixture was neutralized with 5 N aqueous sodium hydroxide solution and then extracted with dichloromethane to give the title compound (698 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299055B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-3e8e20bb7d444874a7b463aec3541926 |
| Source note | uspto-grants-2012_10 |