Hydrogen Bromide → 8-Bromoisoquinolin-6-ol

Participants

Reaction Steps

An aqueous hydrobromic acid (180 mL) solution of Intermediate 6 (30 g) was stirred at 130° C. for 38 hours. The resulting mixture was stirred at room temperature for approx. 10 minutes followed by the addition of water (300 mL) and the precipitate was collected by filtration and dried to give the title compound (21 g).

Provenance & Evidence