Hydrogen Bromide → 8-Bromoisoquinolin-6-ol

HRID 2069082Notes

Reaction equation

HRID 2069082 reaction equation
Br.[Br:2][C:3]1[CH:4]=[C:5]([O:13]C)[CH:6]=[C:7]2[C:12]=1[CH:11]=[N:10][CH:9]=[CH:8]2>O>[Br:2][C:3]1[CH:4]=[C:5]([OH:13])[CH:6]=[C:7]2[C:12]=1[CH:11]=[N:10][CH:9]=[CH:8]2

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 595347478-Bromo-6-methoxyisoquinoline

Product 1

HCID 1357421998-Bromoisoquinolin-6-olYield 74.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

An aqueous hydrobromic acid (180 mL) solution of Intermediate 6 (30 g) was stirred at 130° C. for 38 hours. The resulting mixture was stirred at room temperature for approx. 10 minutes followed by the addition of water (300 mL) and the precipitate was collected by filtration and dried to give the title compound (21 g).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-3b89aa5b6b7d41fbb8a936e0606da989
Source dataset
uspto-grants-2012_10
Patent number
US08299055B2

Reaction notes

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