2-Morpholinoethylamine → HCID 11502825, compound

HRID 2069212Notes

Reaction equation

HRID 2069212 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[N:22]1([CH2:28][CH2:29][NH2:30])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>>[N:22]1([CH2:28][CH2:29][NH:30][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][C:11]=2[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]3=[O:21])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide

Product 1

HCID 11502825HCID 11502825, compoundYield 54%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (29 mg, 0.0912 mmol) is reacted with 2-morpholin-4-yl-ethylamine according to the GPA affording 21 mg (54%) of a red powder. Rt=2.33 min.

Sources & evidence

ORD record
ord-d8678fa68972496a815627e4491a1046
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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