N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide → HCID 11717840, compound

HRID 2069222Notes

Reaction equation

HRID 2069222 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[CH3:22][C:23]1[N:24]=[CH:25][NH:26][CH:27]=1>>[CH3:22][C:23]1[N:24]=[CH:25][N:26]([C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][C:11]=2[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]3=[O:21])[CH:27]=1

Participants

3

Reactant 2

HCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamideHCID 178418800HCID 178418800, compound

Product 1

HCID 11717840HCID 11717840, compoundYield 43%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (25 mg, 0.0786 mmol) is reacted with 4-methyl-1H-imidazole according to the GPB affording 12.6 mg (43%) of a yellowish powder as a 5 to 1 regioisomer mixture. Rt=2.11 min.

Sources & evidence

ORD record
ord-130d209d6760491490bff4b0533878e7
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

Loading…