1-Amino-2-propanol → HCID 11574312, compound

HRID 2069226Notes

Reaction equation

HRID 2069226 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[NH2:22][CH2:23][CH:24]([OH:26])[CH3:25]>>[OH:26][CH:24]([CH3:25])[CH2:23][NH:22][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21]

Participants

3

Reactant 2

HCID 41-Amino-2-propanolHCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide

Product 1

HCID 11574312HCID 11574312, compoundYield 65%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with 1-amino-propan-2-ol according to the GPA affording 23.1 mg (65%) of a red powder. Rt=3.07 min.

Sources & evidence

ORD record
ord-1162bc535a8746d59257ef85d1dad1f2
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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