3-Amino-1-propanol → HCID 69451537, compound

HRID 2069231Notes

Reaction equation

HRID 2069231 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[NH2:22][CH2:23][CH2:24][CH2:25][OH:26]>>[OH:26][CH2:25][CH2:24][CH2:23][NH:22][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21]

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide

Product 1

HCID 69451537HCID 69451537, compoundYield 68.5%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with 3-amino-propan-1-ol according to the GPA affording 24.1 mg (68.5%) of a red powder. Rt=3.09 min.

Sources & evidence

ORD record
ord-98241dc2d9d04934b72db2bb21bc7bfd
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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