Diethanolamine → HCID 11582160, compound

HRID 2069235Notes

Reaction equation

HRID 2069235 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[OH:22][CH2:23][CH2:24][NH:25][CH2:26][CH2:27][OH:28]>>[OH:22][CH2:23][CH2:24][N:25]([CH2:26][CH2:27][OH:28])[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21]

Participants

3

Reactant 2

HCID 8113DiethanolamineHCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide

Product 1

HCID 11582160HCID 11582160, compoundYield 55%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with 2-(2-hydroxy-ethylamino)-ethanol according to the GPA affording 21 mg (55%) of a red powder. Rt=2.36 min.

Sources & evidence

ORD record
ord-3b59ec3a113448049dc27ed87f08a54c
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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