Trifluoroacetic acid → HCID 11552197, compound

HRID 2069238Notes

Reaction equation

HRID 2069238 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][NH:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][C:20]=1[N+:21]([O-:23])=[O:22])[NH:17][C:16](=[O:24])[N:15]([NH:25][S:26]([CH3:29])(=[O:28])=[O:27])[C:14]2=[O:30])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:7][CH2:8][CH2:9][NH:10][C:11]1[CH:12]=[C:13]2[C:18](=[CH:19][C:20]=1[N+:21]([O-:23])=[O:22])[NH:17][C:16](=[O:24])[N:15]([NH:25][S:26]([CH3:29])(=[O:28])=[O:27])[C:14]2=[O:30]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69338207HCID 69338207, compound

Product 1

HCID 11552197HCID 11552197, compoundYield 114.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To an ice-cooled solution of [2-(3-Methanesulfonylamino-7-nitro-2,4-dioxo-1,2,3,4-tetrahydro-quinazolin-6-ylamino)-ethyl]-carbamic acid tert-butyl ester (10 mg, 0.022 mmol) in dichloro-methane (0.5 ml) is added trifluoroacetic acid (0.25 ml). The reaction mixture is stirred at 0° C. for 3 h. The mixture is filtered and the resulting red solid dried under vacuum to afford 9 mg (87%) of a red powder. Rt=2.13 min.

Workup

  1. filtrationThe mixture is filtered
  2. customthe resulting red solid dried under vacuum

Sources & evidence

ORD record
ord-2e35fd2f33454f20b5115f653e27390f
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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