Valinol → HCID 69450639, compound

HRID 2069239Notes

Reaction equation

HRID 2069239 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[NH2:22][CH:23]([CH:26]([CH3:28])[CH3:27])[CH2:24][OH:25]>>[OH:25][CH2:24][CH:23]([NH:22][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21])[CH:26]([CH3:28])[CH3:27]

Participants

3

Reactant 2

HCID 79019ValinolHCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide

Product 1

HCID 69450639HCID 69450639, compoundYield 45%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with 2-amino-3-methyl-butan-1-ol according to the GPA affording 17 mg (45%) of a red powder. Rt=4.00 min.

Sources & evidence

ORD record
ord-e4e76837994144ffbf55d7e048f760ce
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

Loading…