HCID 53977558, compound → HCID 69338360, compound

HRID 2069246Notes

Reaction equation

HRID 2069246 reaction equation
F[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]2=[O:21].[NH2:22][C@H:23]([C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([O:34][CH3:35])[CH:27]=1)[CH2:24][OH:25]>>[CH3:35][O:34][C:28]1[CH:27]=[C:26]([C@@H:23]([NH:22][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][C:11]=2[N+:12]([O-:14])=[O:13])[NH:8][C:7](=[O:15])[N:6]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[C:5]3=[O:21])[CH2:24][OH:25])[CH:31]=[CH:30][C:29]=1[O:32][CH3:33]

Participants

3

Reactant 2

HCID 53977558HCID 53977558, compoundHCID 58964482N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide

Product 1

HCID 69338360HCID 69338360, compoundYield 53%

Procedure

N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with (R)-2-amino-2-(3,4-dimethoxy-phenyl)-ethanol according to the GPA affording 24.8 mg (53%) of a red powder. Rt=3.80 min.

Sources & evidence

ORD record
ord-03a31fe1b1334585b13c811953810593
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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