HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester → 2-Amino-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester | HCID 58964531 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester | HCID 58964524 | 84.9% |
Reaction Steps
300 mg of 2-nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester in 10 ml of dry ethanol are hydrogenated in presence of 60 mg of Raney nickel, After filtration of the catalyst the solution is evaporated to dryness yielding 233 mg of 2-amino-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester as yellow powder, m.p. 85-117° C. (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299085B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-991edd439a7e471bbb5257abb2cef030 |
| Source note | uspto-grants-2012_10 |