HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58964519, compound → HCID 58964492, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58964519 | HCID 58964519 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58964492 | HCID 58964492 | 99.8% |
Reaction Steps
1.10 g of 5-azetidin-1-yl-2-nitro-4-trifluoromethyl-benzoic acid methyl ester in 12 ml of tetrahydrofuran are hydrogenated in presence of 200 mg of palladium on carbon. After 20 filtration of the catalyst the solution is evaporated to dryness yielding 0.99 g of 2-amino-5-azetidin-1-yl-4-trifluoromethyl-benzoic acid methyl ester as yellow powder, m.p. 80-86° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299085B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-549c98c5ca98476881340a72593ae139 |
| Source note | uspto-grants-2012_10 |