HCID 58964519, compound → HCID 58964492, compound

HRID 2069273Notes

Reaction equation

HRID 2069273 reaction equation
[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[C:8]([N:10]2[CH2:13][CH2:12][CH2:11]2)[C:7]([C:14]([F:17])([F:16])[F:15])=[CH:6][C:5]=1[N+:18]([O-])=O>O1CCCC1.[Pd]>[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[C:8]([N:10]2[CH2:11][CH2:12][CH2:13]2)[C:7]([C:14]([F:16])([F:17])[F:15])=[CH:6][C:5]=1[NH2:18]

Participants

4

Reactant 1

HCID 58964519HCID 58964519, compound

Product 1

HCID 58964492HCID 58964492, compoundYield 99.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

1.10 g of 5-azetidin-1-yl-2-nitro-4-trifluoromethyl-benzoic acid methyl ester in 12 ml of tetrahydrofuran are hydrogenated in presence of 200 mg of palladium on carbon. After 20 filtration of the catalyst the solution is evaporated to dryness yielding 0.99 g of 2-amino-5-azetidin-1-yl-4-trifluoromethyl-benzoic acid methyl ester as yellow powder, m.p. 80-86° C.

Workup

  1. filtrationAfter 20 filtration of the catalyst the solution
  2. customis evaporated to dryness

Sources & evidence

ORD record
ord-549c98c5ca98476881340a72593ae139
Source dataset
uspto-grants-2012_10
Patent number
US08299085B2

Reaction notes

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