反应详情

In a similar way a solution of 5-(4-bromo-imidazol-1-yl)-2-nitro-4-trifluoromethyl-benzoic acid methyl ester (300 mg, 0.8 mmol) in 50 ml methanol is hydrogenated over 43 mg of 10% palladium on charcoal to obtain after the usual workup procedure 160 mg (0.466 mmol, 58%) of 2-amino-5-(4-bromo-imidazol-1-yl)-4-trifluoromethyl-benzoic acid methyl ester, m.p. 163-165° C., ES-MS: m/z 365 [M+H]+.