HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Bromo-imidazol-1-yl)-2-nitro-4-trifluoromethyl-benzoic acid methyl ester → 2-Amino-5-(4-bromo-imidazol-1-yl)-4-trifluoromethyl-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Bromo-imidazol-1-yl)-2-nitro-4-trifluoromethyl-benzoic acid methyl ester | HCID 69337582 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-5-(4-bromo-imidazol-1-yl)-4-trifluoromethyl-benzoic acid methyl ester | HCID 58964495 | 58.3% |
Reaction Steps
In a similar way a solution of 5-(4-bromo-imidazol-1-yl)-2-nitro-4-trifluoromethyl-benzoic acid methyl ester (300 mg, 0.8 mmol) in 50 ml methanol is hydrogenated over 43 mg of 10% palladium on charcoal to obtain after the usual workup procedure 160 mg (0.466 mmol, 58%) of 2-amino-5-(4-bromo-imidazol-1-yl)-4-trifluoromethyl-benzoic acid methyl ester, m.p. 163-165° C., ES-MS: m/z 365 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299085B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-76542aba986f43ac8b41b639af576a9c |
| Source note | uspto-grants-2012_10 |