HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Trifluoromethyl-imidazol-1-yl)-2-nitro-4-trifluoromethyl-benzoic acid methyl ester → 2-Amino-5-(4-trifluoromethyl-imidazol-1-yl)-4-trifluoromethyl-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Trifluoromethyl-imidazol-1-yl)-2-nitro-4-trifluoromethyl-benzoic acid methyl ester | HCID 86614858 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Amino-5-(4-trifluoromethyl-imidazol-1-yl)-4-trifluoromethyl-benzoic acid methyl ester | HCID 58964473 | 91.5% |
Reaction Steps
In a similar way a solution of 5-(4-trifluoromethyl-imidazol-1-yl)-2-nitro-4-trifluoromethyl-benzoic acid methyl ester (1.0 g, 2.6 mmol) in 100 ml methanol is hydrogenated over 55 mg of 10% palladium on charcoal to obtain after the usual workup procedure 840 mg (2.38 mmol, 91%) of amorphous 2-amino-5-(4-trifluoromethyl-imidazol-1 -yl)-4-trifluoromethyl-benzoic acid methyl ester, ES-MS: m/z 354 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299085B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-786a20eeeb2542f7ac9ad81df67f32b3 |
| Source note | uspto-grants-2012_10 |