Thionyl Chloride → HCID 87545137, compound

HRID 2069315Notes

Reaction equation

HRID 2069315 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[CH:12][C:11]([C@@H:14]3[CH2:16][C@H:15]3[C:17]([OH:19])=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O>>[ClH:22].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[CH:12][C:11]([C@@H:14]3[CH2:16][C@H:15]3[C:17]([Cl:22])=[O:19])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 59149677HCID 59149677, compound

Product 1

HCID 87545137HCID 87545137, compound

Procedure

200 mg (0.78 mmol) of trans-2-[6-(4-fluoro-phenyl)-pyridin-3-yl]-cyclopropanecarboxylic acid were dissolved in 5 ml of thionyl chloride and heated under reflux for 3 h. The mixture was evaporated to dryness. The residual oil was used in the next step without further purification.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 3 h
  3. customThe mixture was evaporated to dryness
  4. customThe residual oil was used in the next step without further purification

Sources & evidence

ORD record
ord-9b78aa2f0c014d7ebe1783e0f0317765
Source dataset
uspto-grants-2012_10
Patent number
US08299102B2

Reaction notes

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