2-[(2-Phenoxyethyl)Thio]Acetic Acid → Dimethyl-(1-{4-[5-(2-phenoxyethylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl]phenyl}pyrrolidin-3-yl)amine

HRID 2069321Notes

Reaction equation

HRID 2069321 reaction equation
[CH3:1][N:2]([CH3:18])[CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([NH:14][NH2:15])=[O:13])=[CH:10][CH:9]=2)[CH2:4]1.[O:19]([CH2:26][CH2:27][S:28][CH2:29][C:30](O)=O)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH3:1][N:2]([CH3:18])[CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]3[O:13][C:30]([CH2:29][S:28][CH2:27][CH2:26][O:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)=[N:15][N:14]=3)=[CH:10][CH:9]=2)[CH2:4]1

Participants

3

Reactant 2

HCID 27790872-[(2-Phenoxyethyl)Thio]Acetic AcidHCID 692131084-(3-Dimethylaminopyrrolidin-1-yl)benzohydrazide

Product 1

HCID 11495554Dimethyl-(1-{4-[5-(2-phenoxyethylsulfanylmethyl)-[1,3,4]oxadiazol-2-yl]phenyl}pyrrolidin-3-yl)amine

Procedure

4-(3-Dimethylaminopyrrolidin-1-yl)benzohydrazide was reacted with (2-phenoxy-ethylsulfanyl)acetic acid by Method A. The product with the molecular weight of 424.57 (C23H28N4O2S) was obtained in this way; MS (ESI): 425 (M+H+).

Workup

  1. customThe product with the molecular weight of 424.57 (C23H28N4O2S) was obtained in this way

Sources & evidence

ORD record
ord-a240b8acab8b441b8d0c75e7fe358d92
Source dataset
uspto-grants-2012_10
Patent number
US08299104B2

Reaction notes

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