4-Hydroxy-2-methylbenzonitrile → HCID 178429063, compound

HRID 2069416Notes

Reaction equation

HRID 2069416 reaction equation
[CH3:1][C:2]1([CH3:21])[O:6][CH:5]([CH2:7][O:8][C:9]2[C:18](C)=[CH:17][C:12]([C:13]([NH:15][OH:16])=[NH:14])=[CH:11][C:10]=2C)[CH2:4][O:3]1.O[C:23]1C=CC(C#N)=C(C)C=1>>[CH3:21][C:2]1([CH3:1])[O:6][C@H:5]([CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]([C:13]([NH:15][OH:16])=[NH:14])=[C:17]([CH3:23])[CH:18]=2)[CH2:4][O:3]1

Participants

3

Reactant 2

HCID 3087414-Hydroxy-2-methylbenzonitrileHCID 178426655HCID 178426655, compound

Product 1

HCID 178429063HCID 178429063, compound

Procedure

The title compound is obtained as a beige oil (0.65 g) in analogy to rac-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-3,5-dimethyl-benzamidine starting from 4-hydroxy-2-methyl-benzonitrile and L-alpha-beta-isopropyliden glycerol; LC-MS: tR=0.62 min, [M+H]+=281.0.

Sources & evidence

ORD record
ord-c432269e2c2d407a9cfa76c2ddac0d01
Source dataset
uspto-grants-2012_10
Patent number
US08299086B2

Reaction notes

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