Ammonia → 2-Isopropylamino-6-methyl-pyrimidine-4-carboxylic acid amide

HRID 2069421Notes

Reaction equation

HRID 2069421 reaction equation
C([O:3][C:4]([C:6]1[CH:11]=[C:10]([CH3:12])[N:9]=[C:8]([NH:13][CH:14]([CH3:16])[CH3:15])[N:7]=1)=O)C.[NH3:17]>CO>[CH:14]([NH:13][C:8]1[N:7]=[C:6]([C:4]([NH2:17])=[O:3])[CH:11]=[C:10]([CH3:12])[N:9]=1)([CH3:16])[CH3:15]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 685068162-Isopropylamino-6-methyl-pyrimidine-4-carboxylic acid ethyl ester

Product 1

HCID 685093012-Isopropylamino-6-methyl-pyrimidine-4-carboxylic acid amide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-isopropylamino-6-methyl-pyrimidine-4-carboxylic acid ethyl ester (1.46 g, 6.54 mmol) in 3M NH3 in MeOH (50 mL) is stirred at 60° C. for 1 day. Volatiles are evaporated to give the crude 2-isopropylamino-6-methyl-pyrimidine-4-carboxylic acid amide as a pale yellow solid (1.24 g); LC-MS: tR=0.59; [M+H]+=195.0.

Workup

  1. customVolatiles are evaporated

Sources & evidence

ORD record
ord-ab345cbea5eb4d10af3ac3468cf4ac7b
Source dataset
uspto-grants-2012_10
Patent number
US08299086B2

Reaction notes

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