HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Isopropylamino-6-methyl-pyrimidine-4-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Isopropylamino-6-methyl-pyrimidine-4-carboxylic acid ethyl ester | HCID 68506816 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Isopropylamino-6-methyl-pyrimidine-4-carboxylic acid amide | HCID 68509301 | — |
Reaction Steps
A solution of 2-isopropylamino-6-methyl-pyrimidine-4-carboxylic acid ethyl ester (1.46 g, 6.54 mmol) in 3M NH3 in MeOH (50 mL) is stirred at 60° C. for 1 day. Volatiles are evaporated to give the crude 2-isopropylamino-6-methyl-pyrimidine-4-carboxylic acid amide as a pale yellow solid (1.24 g); LC-MS: tR=0.59; [M+H]+=195.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299086B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-ab345cbea5eb4d10af3ac3468cf4ac7b |
| Source note | uspto-grants-2012_10 |