HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → (S)-ethyl 3-methyl-2-(2H-pyrrol-1(5H)-yl)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | l-Valine, ethyl ester | HCID 87182 | — |
| Reactant | 1,4-Dichloro-cis-2-butene | HCID 6432115 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | (S)-ethyl 3-methyl-2-(2H-pyrrol-1(5H)-yl)butanoate | HCID 59180252 | 52% |
Reaction Steps
From L-valine ethyl ester (1.0 g, 6.9 mmol), dichloromethane (1 ml) and cis-1,4-dichloro-2-butene (250 mg, 2.0 mmol). Flash chromatography: silica gel, gradient neat hexane to hexane:ethyl acetate (1:2) afforded the product (205 mg, 52%) as yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299113B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-4462479e4b25449b885dae1bf5bcd500 |
| Source note | uspto-grants-2012_10 |