Dichloromethane → HCID 59180255, compound

HRID 2069486Notes

Reaction equation

HRID 2069486 reaction equation
[CH3:1][O:2][C:3](=[O:10])[C@H:4]([CH2:6][CH:7]([CH3:9])[CH3:8])[NH2:5].ClCCl.Cl[CH2:15]/[CH:16]=[CH:17]\[CH2:18]Cl>CCCCCC.C(OCC)(=O)C>[CH3:8][CH:7]([CH3:9])[CH2:6][C@H:4]([N:5]1[CH2:18][CH:17]=[CH:16][CH2:15]1)[C:3]([O:2][CH3:1])=[O:10]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 65105(+)-L-Leucine methyl esterHCID 64321151,4-Dichloro-cis-2-butene

Product 1

HCID 59180255HCID 59180255, compoundYield 84.5%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

From L-leucine methyl ester (520 mg, 3.56 mmol), dichloromethane (1 ml) and cis-1,4-dichloro-2-butene (135 mg, 1.08 mmol). Flash chromatography: silica gel, gradient hexane:ethyl acetate (3:1 to 1:1) afforded the product (180 mg, 84%) as yellow oil.

Sources & evidence

ORD record
ord-ceb0ecdb07c448deb5bd473070e67032
Source dataset
uspto-grants-2012_10
Patent number
US08299113B2

Reaction notes

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