HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 59180255, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | (+)-L-Leucine methyl ester | HCID 65105 | — |
| Reactant | 1,4-Dichloro-cis-2-butene | HCID 6432115 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 59180255 | HCID 59180255 | 84.5% |
Reaction Steps
From L-leucine methyl ester (520 mg, 3.56 mmol), dichloromethane (1 ml) and cis-1,4-dichloro-2-butene (135 mg, 1.08 mmol). Flash chromatography: silica gel, gradient hexane:ethyl acetate (3:1 to 1:1) afforded the product (180 mg, 84%) as yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299113B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-ceb0ecdb07c448deb5bd473070e67032 |
| Source note | uspto-grants-2012_10 |