Dichloromethane → HCID 11229997, compound

HRID 2069487Notes

Reaction equation

HRID 2069487 reaction equation
[CH3:1][O:2][C:3](=[O:13])[C@H:4]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[NH2:5].ClCCl.Cl[CH2:18]/[CH:19]=[CH:20]\[CH2:21]Cl>CCCCCC.C(OCC)(=O)C>[C:7]1([CH2:6][C@H:4]([N:5]2[CH2:21][CH:20]=[CH:19][CH2:18]2)[C:3]([O:2][CH3:1])=[O:13])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 736234L-Phenylalanine, methyl esterHCID 64321151,4-Dichloro-cis-2-butene

Product 1

HCID 11229997HCID 11229997, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

From L-phenylalanine methyl ester (365 mg, 2.04 mmol), dichloromethane (4 ml) and cis-1,4-dichloro-2-butene (71 mg, 0.58 mmol). Flash chromatography: silica gel, hexane:ethyl acetate (2:1) afforded the product (83 mg, 62%) as colourless oil.

Sources & evidence

ORD record
ord-4adb9a963d3a482db071ab9d474374de
Source dataset
uspto-grants-2012_10
Patent number
US08299113B2

Reaction notes

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