Triphenylphosphine → HCID 86643715, compound

HRID 2069632Notes

Reaction equation

HRID 2069632 reaction equation
[Cl:1][CH2:2][C:3]1[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=2[CH:6]=[C:5]([F:14])[CH:4]=1.[C:15]1([P:21]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C=CC=CC=1>[Cl-:1].[F:14][C:5]1[CH:4]=[C:3]([CH2:2][P+:21]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:11]2[O:10][C:9]([CH3:13])([CH3:12])[CH2:8][C:7]=2[CH:6]=1

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 58566560HCID 58566560, compound

Product 1

HCID 86643715HCID 86643715, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

7-(chloromethyl)-5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran (647) (1 g, 4.66 mmol), triphenyl phosphine (1.22 g, 4.66 mmol) and toluene (46 mL) were heated at reflux for 48 hours. The reaction was filtered and the solid was washed with diethyl ether to provide ((5-fluoro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)methyl)triphenyl phosphonium chloride (648).

Workup

  1. temperatureat reflux for 48 hours
  2. filtrationThe reaction was filtered
  3. washthe solid was washed with diethyl ether

Sources & evidence

ORD record
ord-8cd014e64ec64973812ed77679aa9717
Source dataset
uspto-grants-2012_10
Patent number
US08299117B2

Reaction notes

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