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温度

0 °C

To a suspension of compound III (0.26 g, 0.76 mmol) in 15 ml dry THF which was cooled at 0° C. in an ice bath, was added a solution of superhydride 1M (1.5 ml, 1.5 mmol) in THF. After stirring for 0.5 hour at 0° C. the reaction was quenched with saturated ammonium chloride and diluted with ethyl acetate. The organic phase was washed with brine, dried over sodium sulfate and concentrated to give 0.25 g (96% yield) of IV which was used in the next step without further purification.

1. customwas quenched with saturated ammonium chloride
2. additiondiluted with ethyl acetate
3. washThe organic phase was washed with brine
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated