Dichloromethane → Valine methyl ester

HRID 2069991Notes

Reaction equation

HRID 2069991 reaction equation
Cl.[NH2:2][C@H:3]([C:7]([OH:9])=[O:8])[CH:4]([CH3:6])[CH3:5].Cl[CH2:11]Cl>>[CH3:11][O:8][C:7](=[O:9])[C@H:3]([CH:4]([CH3:6])[CH3:5])[NH2:2]

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 13000930Valine--hydrogen chloride (1/1)

Product 1

HCID 94285Valine methyl ester

Procedure

500 mg of methyl ester of L-(+)-valine hydrochloride are placed in a round-bottom flask. 45 mL of buffer solution (K2HPO4/K3PO4 (pH=12.4)), then 22.5 mL of anhydrous dichloromethane are successively added. The mixture is agitated at room temperature for 30 min. The organic phase is separated, washed with brine, dried on magnesium sulfate, filtered and concentrated under vacuum.

Workup

  1. customThe organic phase is separated
  2. washwashed with brine
  3. customdried on magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-21885dc629d74c55b99e3a5e8f9ffdb8
Source dataset
uspto-grants-2012_10
Patent number
US08299250B2

Reaction notes

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