diethyl ({[1-(4-methoxybenzyl)-1H-pyrazol-5-yl]amino}methylidene)propanedioate → HCID 178469630, compound

Participants

Reaction Conditions

Reaction Steps

2-{([2-(4-Methoxybenzyl)-2H-pyrazol-3-ylamino]methylene}malonic acid diethyl ester (7.0 g) was dissolved in diphenyl ether (about 21 mL), the resulting mixture was stirred at 240° C. for 5 hours. The reaction solution was purified by silica-gel column chromatography (dichloromethane/methanol=100/0 to 100/1) to give 4-hydroxy-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (4.0 g, yield: 65%) as a light-yellow powder.

Provenance & Evidence