反应详情

温度

240 °C

2-{([2-(4-Methoxybenzyl)-2H-pyrazol-3-ylamino]methylene}malonic acid diethyl ester (7.0 g) was dissolved in diphenyl ether (about 21 mL), the resulting mixture was stirred at 240° C. for 5 hours. The reaction solution was purified by silica-gel column chromatography (dichloromethane/methanol=100/0 to 100/1) to give 4-hydroxy-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (4.0 g, yield: 65%) as a light-yellow powder.

1. customThe reaction solution was purified by silica-gel column chromatography (dichloromethane/methanol=100/0 to 100/1)