反应详情

温度

60 °C

4-[1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy]aniline (263 mg) was dissolved in TFA (7.5 mL). The resulting mixture was stirred at 60° C. for 2 hours and concentrated under reduced pressure. The residue was diluted with dichloromethane and then washed with a sodium bicarbonate solution and saturated brine. The organic layer was separated and concentrated under reduced pressure. The residue was suspended in ether, and the precipitate was collected by filtration to give 4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)aniline (151 mg, yield: 88%) as a light-brown powder.

1. concentrationconcentrated under reduced pressure
2. additionThe residue was diluted with dichloromethane
3. washwashed with a sodium bicarbonate solution and saturated brine
4. customThe organic layer was separated
5. concentrationconcentrated under reduced pressure
6. filtrationthe precipitate was collected by filtration