HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Fluoropropyl)-4-nitro-2-(trifluoromethyl)benzene → 4-(3-Fluoropropyl)-3-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Fluoropropyl)-4-nitro-2-(trifluoromethyl)benzene | HCID 59398521 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(3-Fluoropropyl)-3-(trifluoromethyl)aniline | HCID 59398525 | 93% |
Reaction Steps
1-(3-Fluoropropyl)-4-nitro-2-(trifluoromethyl)benzene (300 mg, 1.8 mmol) was dissolved in methanol (10 mL), and palladium carbon (10%, 60 mg) was added thereto. The resulting mixture was stirred under hydrogen atmosphere at room temperature for 3 hours. The catalyst was removed by filtration to give 4-(3-fluoropropyl)-3-(trifluoromethyl)aniline (247 mg, 93%) as a light-yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299252B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-911d1a1605c344e58d5830987f264512 |
| Source note | uspto-grants-2012_10 |