HCID 59398561, compound → HCID 59398567, compound

HRID 2070037Notes

Reaction equation

HRID 2070037 reaction equation
C(OC(=O)[NH:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][F:19])=[C:13]([C:20]([F:23])([F:22])[F:21])[CH:12]=1)C1C=CC=CC=1>CO.[C].[Pd]>[F:19][CH2:18][CH2:17][C:14]1[CH:15]=[CH:16][C:11]([NH2:10])=[CH:12][C:13]=1[C:20]([F:21])([F:22])[F:23]

Participants

4

Reactant 1

HCID 59398561HCID 59398561, compound

Product 1

HCID 59398567HCID 59398567, compoundYield 29.6%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

[4-(2-Fluoroethyl)-3-(trifluoromethyl)phenyl]carbamic acid benzyl ester (194 mg, 0.8 mmol) was dissolved in methanol (4 mL), and palladium carbon (10%, 45 mg) was added thereto. The resulting mixture was stirred under hydrogen atmosphere at room temperature for 3 hours. The catalyst was removed by filtration to give 4-(2-fluoroethyl)-3-(trifluoromethyl)aniline (49 mg, 29%) as a light-yellow oil.

Workup

  1. customThe catalyst was removed by filtration

Sources & evidence

ORD record
ord-5ff1d50f191b4cb5bf744cfe6694612f
Source dataset
uspto-grants-2012_10
Patent number
US08299252B2

Reaction notes

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