HCID 72288086, compound → HCID 59398529, compound

HRID 2070044Notes

Reaction equation

HRID 2070044 reaction equation
C(OC(=O)[NH:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]=[CH:18][C:19]([F:22])([F:21])[F:20])=[C:13]([C:23]([F:26])([F:25])[F:24])[CH:12]=1)C1C=CC=CC=1>CO.[C].[Pd]>[F:24][C:23]([F:25])([F:26])[C:13]1[CH:12]=[C:11]([CH:16]=[CH:15][C:14]=1[CH2:17][CH2:18][C:19]([F:22])([F:21])[F:20])[NH2:10]

Participants

4

Reactant 1

HCID 72288086HCID 72288086, compound

Product 1

HCID 59398529HCID 59398529, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

[3-(Trifluoromethyl)-4-(3,3,3-trifluoropropenyl)phenyl]carbamic acid benzyl ester (103 mg, 0.27 mmol) was dissolved in methanol (10 mL), and palladium carbon (10%, 11 mg) was added thereto. The resulting mixture was stirred under hydrogen atmosphere at room temperature for 3 hours. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure to give 3-(trifluoromethyl)-4-(3,3,3-trifluoropropyl)aniline (56.6 mg, 83%) as a light-yellow oil.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ce8a859af3744c2f9672cf56423d3022
Source dataset
uspto-grants-2012_10
Patent number
US08299252B2

Reaction notes

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