HCID 67421830, compound → HCID 46214207, compound

HRID 2070068Notes

Reaction equation

HRID 2070068 reaction equation
[CH2:1]([NH:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20]CC3C=CC=CC=3)=[CH:16][C:15]=2[O:28]CC2C=CC=CC=2)[CH2:10][CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4]>CO.[Pd]>[CH2:1]([NH:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][C:15]=2[OH:28])[CH2:12][CH2:13]1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 67421830HCID 67421830, compound

Product 1

HCID 46214207HCID 46214207, compoundYield 90.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In a 25 ml round-bottomed flask, 0.25 g of 4-(2,4-bis(benzyloxy)phenyl)piperidine-1-carboxylic acid butylamide is dissolved in 9 ml of methanol in the presence of 0.1 g of palladium-on-charcoal at 10%. The reaction mixture is stirred for 4 hours under a hydrogen atmosphere. The reaction mixture is filtered. 0.14 g of 4-(2,4-dihydroxyphenyl)piperidine-1-carboxylic acid butylamide is obtained. Yield=90%.

Workup

  1. filtrationThe reaction mixture is filtered

Sources & evidence

ORD record
ord-6086bcb8c3ad4e5289962b95c50918fb
Source dataset
uspto-grants-2012_10
Patent number
US08299259B2

Reaction notes

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