反应详情

Aqueous hydrochloric acid-ethanol solution was prepared (from commercial aqueous concentrated hydrochloric acid (3 L) and ethanol (6 L)), and N-(6-bromo-8-nitro-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)acetamide (known compound: Chem. Abst., 4150 (1947)) (604 g) was added to the solution, followed by heating for 14 hours under stirring and reflux. The reaction mixture was cooled on an ice bath, and the precipitates were recovered through filtration. The thus-obtained solid was washed with ethanol and dried, whereby the title compound (571 g) was yielded as a powdery compound.

1. additionwas added to the solution
2. temperatureby heating for 14 hours
3. temperaturereflux
4. temperatureThe reaction mixture was cooled on an ice bath
5. filtrationthe precipitates were recovered through filtration
6. washThe thus-obtained solid was washed with ethanol
7. customdried