反应详情

温度

70 °C

(2R)-2-(2-Amino-2-methylpropanamido)-4-methyl-N-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]pentanamide (542 mg) was dissolved in ethyl acetate (6.5 mL), and (R)-(−)-mandelic acid (141 mg) was added thereto. The mixture was stirred at 70° C. for 10 minutes, and then left to stand to cool to room temperature. The formed precipitates were recovered through filtration, washed with ethyl acetate, and dried under reduced pressure, whereby the title compound (589 mg) was yielded.

1. waitleft
2. temperatureto cool to room temperature
3. customThe formed precipitates
4. filtrationwere recovered through filtration
5. washwashed with ethyl acetate
6. dry with materialdried under reduced pressure, whereby the title compound (589 mg)
7. customwas yielded