(2-Methyl-5-nitrophenyl)pyrrolidine → 4-Methyl-3-(pyrrolidin-1-yl)aniline

HRID 2070342Notes

Reaction equation

HRID 2070342 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>CO.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 69558510(2-Methyl-5-nitrophenyl)pyrrolidine

Product 1

HCID 176040494-Methyl-3-(pyrrolidin-1-yl)aniline

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The mixture containing (2-methyl-5-nitrophenyl)pyrrolidine in methanol with catalytic amount of 10% Pd/C was hydrogenated to yield 4-methyl-3-pyrrolidinylphenylamine.

Sources & evidence

ORD record
ord-a5e800b91c0644ab91b8f80f4d3cf579
Source dataset
uspto-grants-2012_10
Patent number
US08299108B2

Reaction notes

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