4-[4-(Methylamino)-3-nitrophenoxy]pyridine-2-carboxamide → 4-(3-Amino-4-(methylamino)phenoxy]pyridine-2-carboxamide

HRID 2070347Notes

Reaction equation

HRID 2070347 reaction equation
[CH3:1][NH:2][C:3]1[CH:18]=[CH:17][C:6]([O:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([C:14]([NH2:16])=[O:15])[CH:9]=2)=[CH:5][C:4]=1[N+:19]([O-])=O>CO.[Pd]>[NH2:19][C:4]1[CH:5]=[C:6]([CH:17]=[CH:18][C:3]=1[NH:2][CH3:1])[O:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([C:14]([NH2:16])=[O:15])[CH:9]=1

Participants

4

Reactant 1

HCID 597899824-[4-(Methylamino)-3-nitrophenoxy]pyridine-2-carboxamide

Product 1

HCID 220403554-(3-Amino-4-(methylamino)phenoxy]pyridine-2-carboxamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The mixture containing 4-[4-(methylamino)-3-nitrophenoxy]pyridine-2-carboxamide in methanol with catalytic amount of 10% Pd/C was hydrogenated to yield 4-(3-amino-4-(methylamino)phenoxy]pyridine-2-carboxamide.

Sources & evidence

ORD record
ord-d8a1b9ccf1304174a5770f772489c449
Source dataset
uspto-grants-2012_10
Patent number
US08299108B2

Reaction notes

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