2-Bromo-4-nitro-1-(2,2,2-trifluoroethoxy)benzene → HCID 60098084, compound

HRID 2070350Notes

Reaction equation

HRID 2070350 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[O:11][CH2:12][C:13]([F:16])([F:15])[F:14]>CCOC(C)=O>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[O:11][CH2:12][C:13]([F:15])([F:16])[F:14]

Participants

3

Reactant 1

HCID 600980072-Bromo-4-nitro-1-(2,2,2-trifluoroethoxy)benzene

Product 1

HCID 60098084HCID 60098084, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-Bromo-4-nitro-1-(2,2,2-trifluoro-ethoxy)-benzene was dissolved in EtOAc, purged with nitrogen, and a catalytic amount of Pd on Carbon added. The solution is purged a number of times, then left to stir overnight under an atmosphere of nitrogen. The solution is filtered through Celite and concentrated yielding the desired product in quantitative yield. LC Rt=1.852 min. MH+=270.0

Workup

  1. custompurged with nitrogen
  2. additiona catalytic amount of Pd on Carbon added
  3. customThe solution is purged a number of times
  4. waitleft
  5. filtrationThe solution is filtered through Celite
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-f256eb1eb53e4ecab8088e1c27857c06
Source dataset
uspto-grants-2012_10
Patent number
US08299108B2

Reaction notes

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