HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
O-(Trimethylsilyl)hydroxylamine → 2-(4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2h-chromen-8-yloxy)-n-hydroxyacetamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | O-(Trimethylsilyl)hydroxylamine | HCID 2734666 | — |
| Edukt | 2-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)acetic acid | HCID 24849714 | — |
| Produkt | 2-(4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2h-chromen-8-yloxy)-n-hydroxyacetamide | HCID 24849298 | — |
Reaktionsschritte
The title compound was prepared from 2-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)acetic acid (Example 49) following the procedure outlined in Example 84 (except TMSONH2 in place of NH2OH•HCl). 1H NMR (400 MHz, DMSO-d6): δ 10.64 (s, 1H), 9.54 (s, 1H), 8.82 (s, 2H), 7.97 (d, 1H), 7.23 (d, 1H), 4.65 (s, 1H), 4.43 (s, 2H), 3.93 (s, 3H); MS (ESI): 425.8.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07745646B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-dd4eaaf0ab534f9991e7c46dc04f5473 |
| Quellennotiz | uspto-grants-2010_06 |