反应详情

To a stirred solution of 3-(3,5-dichloro-2-oxo-1(2H)-pyrazinyl)-4-methyl-benzoic acid, methyl ester, (Example 107a, 250 mg) in acetonitrile (5 mL) was added 1-methyl-piperazine (0.2 mL). After 12 h, the reaction mixture was concentrated in vacuo. The residue was diluted with dichloromethane, washed with sat. aqueous NaHCO3, dried (MgSO4), filtered and the solvent removed to afford the subtitle compound. MS: APCI(+ve) 377 (M+H+).

1. concentrationthe reaction mixture was concentrated in vacuo
2. additionThe residue was diluted with dichloromethane
3. washwashed with sat. aqueous NaHCO3
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. customthe solvent removed