HRID2070921

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81184

1,8-Diazabicyclo[5.4.0]undec-7-ene

C9H16N2

反应SMILES：[N-]=[N+]=NP(=O)(c1ccccc1)c1ccccc1

HCID199401

Phosphinic azide, diphenyl-

C12H10N3OP

HCID17750909

(4-Methyl-1,3-thiazol-2-yl)methanol

C5H7NOS

PRODUCTS

产物

HCID57486671

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

Diphenylphosphoryl azide (DPPA) (1.2 eq) and 1,8-Diazabicyclo(5.4.0)undec-7-ene (DBU) (1.2 eq) were added to a stirred solution of (4-methylthiazol-2-yl)methanol (1 eq) in 7 ml anh. toluene under Ar. After stirring overnight, the solvent was removed in vacuo. Purification via flash chromatography yielded 2-(azidomethyl)-4-methylthiazole.

WORKUP

后处理

customthe solvent was removed in vacuo
customPurification via flash chromatography