反应详情

A mixture of 154 mg (1.07 mmol) of 2-(prop-1-en-2-yl)isonicotinonitrile and 19.2 mg of 10% Pd/C with 1.7 mL of 1.25 N HCl in 10 mL of MeOH was stirred at r.t. under H2 balloon for 14 h. The mixture was filtered through Celite and concentrated. Saturated NaHCO3 was added, and the mixture concentrated with methanol, filtered through a sintered funnel, and reconcentrated to give 95.1 mg of crude (2-isopropylpyridin-4-yl)methanamine which was used without further purification.

1. filtrationThe mixture was filtered through Celite
2. concentrationconcentrated
3. additionSaturated NaHCO3 was added
4. concentrationthe mixture concentrated with methanol
5. filtrationfiltered through a sintered funnel