反应详情

To stirring solution of 233 mg (1.70 mmol) of 5-methylnicotinic acid (synthesized following the general procedure for 5-fluoro-isophthalic acid) in 30 mL of THF at 0° C. was added 181 mg (4.76 mmol) of LiAlH4. After 25 min., the reaction was quenched by adding successively 180 μL of H2O, 180 μL of 15% aqueous NaOH, and 540 μL of brine. The mixture was filtered through Celite and concentrated to give 87 mg of (5-methylpyridin-3-yl)methanol which was used for the next reaction without further purification.

1. customsynthesized
2. customat 0° C.
3. customthe reaction was quenched
4. additionby adding successively 180 μL of H2O, 180 μL of 15% aqueous NaOH, and 540 μL of brine
5. filtrationThe mixture was filtered through Celite
6. concentrationconcentrated