HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(tert-Butyl)benzonitrile → (3-(tert-Butyl)phenyl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(tert-Butyl)benzonitrile | HCID 140731 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ammonium Hydroxide | HCID 14923 | — |
| Product | (3-(tert-Butyl)phenyl)methanamine | HCID 8167069 | — |
Reaction Steps
To 3-tert-butylbenzonitrile (400 mg) in MeOH (5 mL), aqueous ammonium hydroxide (1 mL) and Raney Nickel (catalytic) were added and the reaction mixture was hydrogenated at 50 psi for 2 h. Then the reaction mixture was filtered and solvent evaporated. (3-tert-butylphenyl)methanamine was used without any purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08299267B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-bbc72d039ee94c15a853aef909dfd47b |
| Source note | uspto-grants-2012_10 |