反应详情

To a solution of (R)-tert-butyl 1-(4-(iodomethyl)oxazol-2-yl)ethylcarbamate (660 mg, 1.87 mmol) in HMPA (10 mL), was added NaCNBH3 (470 mg, 7.5 mmol). The reaction was stirred for 4 h. and poured into ice-cold water and extracted with hexanes. The organic layer was dried on Na2SO4, concentrated, and chromatographed on silica gel (10% ethyl acetate/90% hexanes) to yield 38% of (R)-tert-butyl 1-(4-methyloxazol-2-yl)ethylcarbamate.

1. additionpoured into ice-cold water
2. extractionextracted with hexanes
3. customThe organic layer was dried on Na2SO4
4. concentrationconcentrated
5. customchromatographed on silica gel (10% ethyl acetate/90% hexanes)