反应详情

To tert-butyl (5-cyanopyridin-3-yl)methylcarbamate in CH2Cl2 (10 ml), TFA (3 ml) was added. After 1 h, volatiles were removed on a rotavap under reduced pressure. Crude residue was dissolved in water, basified with 2N NaOH and extracted with CHCl3 (100 ml) to obtain 5-(aminomethyl)nicotinonitrile which was used without further purification.

1. customvolatiles were removed on a rotavap under reduced pressure
2. dissolutionCrude residue was dissolved in water
3. extractionextracted with CHCl3 (100 ml)