Benzyloxycarbonyl-L-proline → HCID 23591381, compound

HRID 2071106Notes

Reaction equation

HRID 2071106 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([C@H:7]2[CH2:11][CH2:10][CH2:9][NH:8]2)[S:5][CH:6]=1.C(N1CCC[C@H]1C(O)=O)(OCC1C=CC=CC=1)=O>>[CH3:1][C:2]1[N:3]=[C:4]([C@@H:7]2[CH2:11][CH2:10][CH2:9][NH:8]2)[S:5][CH:6]=1

Participants

3

Reactant 2

HCID 101987Benzyloxycarbonyl-L-prolineHCID 42078478HCID 42078478, compound

Product 1

HCID 23591381HCID 23591381, compound

Procedure

(S)-4-methyl-2-(pyrrolidin-2-yl)thiazole was prepared following the same procedure as in the preparation of (R)-4-methyl-2-(pyrrolidin-2-yl)thiazole starting from the commercially available Cbz-L-proline (Aldrich).

Sources & evidence

ORD record
ord-c127b10a0f0943cea08f111da95f5fa3
Source dataset
uspto-grants-2012_10
Patent number
US08299267B2

Reaction notes

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